​​Thank you for your question about CMS506. 1. Unfortunately, we cannot confirm which RxNorm code should be used in your first example because it could be one of many codes in the value set. The drug is typically mixed with normal saline so the hydromorphone mg is dependent on the mg of vials/pre-filled syringes available and amount of saline used. For example, say that the vials available are 2 mg/mL and we are using 36 mL of normal saline, so we need 4 vials of 2 mg/mL of hydromorphone. This means the applicable RxNorm code be any one of the following codes: 1724276, 897745, 897757. In this case, 8 mg/36 mL of NS = 0.2 mg/hr when set up this way on the PCA. Another possibility is that only 10 mg/mL vials of hydromorphone (1724338) was available, only 1 vial is needed but 50 mL NS is needed to mix: 10 mg hydromorphone/50 mL of NS = 0.2 mg/hr when set up this way on the PCA. The type of PCA may also make a difference in which RxNorm code is applicable. We recommend confirming any proposed mapping with a pharmacist and if mapping is done, you should maintain documentation in case of a CMS audit. 2. In the second scenario, we cannot confirm how to best map 2 Lorazepam 2mg/mL; one code uses injection and the other injectable solution. We recommend confirming your RxNorm mapping with a pharmacist and if mapping is done, you should maintain documentation in case of a CMS audit. However, we can confirm that in the case of benzodiazepines, having the same medication mapped to more than one RxNorm code will not affect whether an encounter is in the numerator. Only patient encounters discharged with a benzodiazepine and opioid or two or more opioids would be in the numerator. Please let us know if you have additional questions.