The use of PSA tests for screening is very valuable. As a nurse I have seen many patients diagnosed with high grade prostate cancers due to a simple PSA test which lead to biopsy. Many intermediate and high risk prostate cancers will go undetected without PSA screening and will be found only when progressed to other parts of the body (metastatic). What the U.S. Preventative Services Task Force (USPSTF) fails to address is living with advanced prostate cancer. The only area they look at is mortality. Living with metastatic prostate cancer can be devastating. Yes the person may die of something else but suffer with excruciating pain for years that could have been prevented. In the United States, the rate of advanced cancer at the time of diagnosis has fallen 75% since the PSA screening era began, more than for any other cancer. Age-adjusted prostate cancer death rates have declined 37% percent. Statistical studies suggest that 45-70 percent of this decrease is due to PSA screening.If screening detected only harmless cancers, treating them could not produce the striking decline in prostate cancer death rates that has occurred. (Catalona)