Thank you for your question about CMS506v3 Safe Use of Opioids – Concurrent Prescribing. The intent of the measure is to exclude people with active cancer. Cancer is identified in two different ways in the logic - through a cancer prevalence period and through the diagnosis code for the inpatient stay. If the patient has a diagnosis code for cancer and their record is not updated to indicate the cancer had abated, the measure logic would assume the cancer prevalence period is continuing through the relevant inpatient stay and exclude the patient. Because the intent of the measure is to exclude only active cases of cancer, we recommend adding cancer abatement dates when the patient is in remission or recovered so the patient will not be improperly excluded. Please let us know if you have additional questions. Denominator Exclusion /*Excludes encounters of patients with cancer or who are receiving palliative or hospice care at the time of the encounter*/ "Inpatient Encounter with Age Greater than or Equal to 18" InpatientEncounter   where exists ( ["Diagnosis": "All Primary and Secondary Cancer"] Cancer       where Cancer.prevalencePeriod overlaps InpatientEncounter.relevantPeriod   )     or exists ( "Inpatient Encounter with Age Greater than or Equal to 18" InpatientEncounter         where exists InpatientEncounter.diagnoses Diagnosis           where Diagnosis.code in "All Primary and Secondary Cancer"​